Project description:In Cystic Fibrosis (CF) patients, cycles of infection and inflammation lead to fatal lung damage. Here, we made use of a CF pig model to investigate proteome alterations in lung, lung-derived leukocytes and PBMCs.
Project description:Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung condition with an unpredictable disease course. The pathology of IPF starts in the lung bases such that a patient’s lung apices are comparatively less fibrotic at the time of transplantation. We hypothesized that RNA sequencing of the lung apices and bases may identify differentially expressed genes that better reflect disease progression in IPF. Samples were derived from both right and left lungs when available and RNA Seq was performed on a total of 139 samples.