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GNPS - System Wide MS course

ABSTRACT: This dataset consist 960 untargted LC-MS/MS runs of human skin swabs and environmental swabs of human habitats. The data was generated in the context of the System Wide MS course at UC San Diego (Skaggs School of Pharmacy).

INSTRUMENT(S): Orbitrap (Q-Exactive)

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Environmental Samples <bacillariophyta> (ncbitaxon:33858)

SUBMITTER: System Wide MS course

PROVIDER: MSV000079697 | GNPS | Tue May 03 11:24:00 BST 2016

REPOSITORIES: GNPS

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GNPS - System Wide MS course (QqQ)

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Inhibition of histone deacetylation by MS-275 alleviates colitis by activating the vitamin D receptor

Project description:BACKGROUND: Ulcerative colitis (UC) is a common chronic inflammatory bowel disease without curative treatment. METHODS: We conducted gene set enrichment analysis to explore potential therapeutic agent for UC. Human colon tissue samples were collected to test H3 acetylation in UC. Both in vivo and in vitro colitis models were constructed to verify the role and mechanism of H3 acetylation modification in UC. Intestine-specific vitamin D receptor (VDR)-/- mice and VD (vitamin D)-deficient diet-fed mice were used to explore downstream molecular mechanism accordingly. RESULTS: According to the Connectivity Map database, MS-275 (class I histone deacetylase inhibitor) was the top-ranked agent, indicating potential importance of histone acetylation in the pathogenesis of UC. We then found that histone H3 acetylation was significantly decreased in the colon epithelium of UC patients and negatively associated with disease severity. MS-275 treatment inhibited histone H3 deacetylation, and subsequently attenuated nuclear factor kappa B (NF-?B)-induced inflammation, reduced cellular apoptosis, maintained epithelial barrier function, and thereby reduced colitis activity in a mouse model of colitis. We also identified VDR to be a downstream effector of MS-275. The curative effect of MS-275 on colitis was abolished in VDR-/- mice and in VD-deficient diet-fed mice and VDR directly targeted p65. In UC patients, histone H3 acetylation, VDR and zonulin-1 expression showed similar downregulation patterns and were negatively associated with disease severity. CONCLUSION: We demonstrate that MS-275 inhibits histone deacetylation and alleviates colitis by ameliorating inflammation, reducing apoptosis and maintaining intestinal epithelial barrier via VDR, providing new strategies for UC treatment.

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GNPS System Wide MS course Group 3 Person 1 through 3

Project description:Human samples collected by Group 3 in the spring 2016 System Wide MS course. Samples contain swabs of three individuals.

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GNPS-System Wide MS Course Group 5 Person 1 through 2

Project description:For System Wide MS Course given by Pieter C. Dorrestein at UCSD, this dataset is comprised of untargeted LC-MS/MS runs of human skin swabs following interaction with public drinking fountains.

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