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GNPS Qinichelins, novel catecholate-hydroxamate siderophores

ABSTRACT: A novel group of catecholate-hydroxymate siderophores, termed qinichelins, from Streptomyces sp. MBT76 were identified. Correlation between metabolite levels and the protein expression profiles [PXD006577] identified the biosynthetic gene cluster qch. responsible for qinichelin biosynthesis. The genome of sp. MBT76 contained two gene clusters for the production of the catecholate-peptide siderophores (qinichelins and griseobactin) and a separate cluster for the production of the shared catecholate precursor. In addition, an operon in the qch cluster was identified for the production of the ornithine precursor for qinichelins, independent of primary metabolism. This biosynthetic complexity provides new insights into the challenges scientists face when applying synthetic biology approaches for natural product discovery.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Streptomyces Sp. Mbt76

SUBMITTER: Gilles van Wezel

PROVIDER: MSV000081504 | GNPS |

REPOSITORIES: GNPS

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