Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS - SEED Grant - Kim - very low birth weight infants

ABSTRACT: Very low birth weight infant fecal samples. Samples were extracted with ethanol and processed on a Thermo Q-exactive mass spectrometer coupled to C18 RP-UPLC for untargeted metabolomic analysis. Positive polarity acquisition of LC-MS/MS.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jae Kim

PROVIDER: MSV000083559 | GNPS | Tue Mar 12 12:47:00 GMT 2019

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Extremelly low birth weight infant gut microbiome

Project description:16S rRNA gene sequencing of Extremelly low birth weight infant

| PRJEB17783 | ENA

Extremely low birth weight infant gut microbiome

Project description:16S rRNA gene sequencing in extremely low birth weight infant gut

| PRJEB17754 | ENA

Molecular markers of predictive value associated with low birth weight

Project description:Sub-optimal fetal development is associated with an increased risk of developing cardiovascular disease, type 2 diabetes (T2D) and adiposity later in life. However, definitions of intrauterine growth restriction (IUGR) and small for gestational age (SGA) are based on simple statistical approaches that may misclassify infants with a normal developmental profile and vice versa. We used an unbiased global profiling approach to identify gene expression patterns in umbilical cord tissue from 38 infants and identified a set of 466 genes which separated the subjects into 2 distinct groups – one biased towards lower birth weight and one biased towards normal birth weight. The data suggest that approximately 30% of children of normal size have a molecular profile more typical of impaired fetal development and who may be on a programmed trajectory. Differences in expression between the two groups encompassed 384 upregulated and 82 downregulated genes. Molecular profiling at birth may have utility in identifying markers that potentially reflect antenatal developmental and may be predictive of future phenotypic development after birth. Importantly, it may provide an alternative to the current classification of infants using birth weights. RNA from umbilical cord tissue from full term neonates was extracted and hybridized. Separation into 2 distinct groups, independent of birth weight, but based solely on gene expression levels was analysed by Genespring. After appropriate statistical analysis, one group was keenly associated with a higher birth weight (22 samples) while the other was associated with a lower birth-weight (18 samples). Technical replicates were included for all 40 samples.

2011-10-20 | E-GEOD-24818 | biostudies-arrayexpress

Genome-Wide Expression Profiles in Very Low Birth Weight Infants With Neonatal Sepsis

Project description:Bacterial sepsis is associated with high morbidity and mortality in preterm infants. However, diagnosis of sepsis and identification of the causative agent remains challenging. Our aim was to determine genome-wide expression profiles of very low birth weight (VLBW) infants with and without bacterial sepsis and assess differences.

2016-05-29 | E-MTAB-4785 | biostudies-arrayexpress

gut microbiota in very low birth weight preterm infants

Project description:Impact of early empiric antibiotic use on the gut microbiota in very low birth weight preterm infants

| PRJEB39732 | ENA

gut microbiota in very low birth weight preterm infants

Project description:Impact of early empiric antibiotic use on the gut microbiota in very low birth weight preterm infants

| PRJEB39734 | ENA

Extremelly birth weight infant gut

Project description:16S rRNA gene sequencing of the extremelly birth weight infant gut

| PRJEB17882 | ENA

Gene expression study reveals compromised Pattern Recognition Receptors and Interferon Signaling in fullterm Low birth Weight newborns

Project description:Low Birth Weight (LBW) newborns (with weight less than 2500g) suffer a higher frequency and severity of microbial infection than normal birth weight (NBW) newborns. Morbidity and mortality of LBW infants due to infectious diseases are known to be high and it has been associated with compromised immune functions, however, the complete understanding of the cause is lacking. We, therefore, conducted a gene expression study to identify all the defective pathways and functions in the LBW newborns using DNA microarray. RNA were isolated from the umbilical cord blood of the NBW and LBW newborns and processed for chip hybridisation. Our results suggest down-regulation of genes participating in several canonical pathways vital in the defense response against microbes and perpetuation of immune responses. Pattern recognition receptors (PRRs) and Interferon signaling appear to be most significantly impacted pathways. The information generated from this study may help in depth understanding of the cause of higher frequency of infections in LBW and thus, in turn help devise better therapeutic interventions.

2012-01-15 | GSE29807 | GEO

Gene expression study reveals compromised Pattern Recognition Receptors and Interferon Signaling in fullterm Low birth Weight newborns

2012-01-15 | E-GEOD-29807 | biostudies-arrayexpress

Molecular markers of predictive value associated with low birth weight

2011-10-21 | GSE24818 | GEO