ABSTRACT: A comparative global natural products social (GNPS) molecular networking analysis of 63 co-isolated fungi guided the isolation of new scopularides C-G from Beauveria sp. CMB-F585
Project description:A comparative global natural products social (GNPS) molecular networking analysis of 63 co-isolated fungi guided the isolation of new scopularide H and known scopularide A from Scopulariopsis sp. CMB-F115
Project description:A comparative global natural products social (GNPS) molecular networking analysis of 63 co-isolated fungi guided isolation of new scopularides C-H and the known scopularides A and B from Scopulariopsis spp. CMB-F458 and CMB-F115, and Beauveria sp. CMB-F585
Project description:Chemical investigation of Scopulariopsis sp. CMB-F458 yielded the known scopularides A and B, coupled with a comparative global natural products social (GNPS) molecular networking analysis of 63 co-isolated fungi guided the isolation of six new scopularides C-H from Beauveria sp. CMB-F585 and Scopulariopsis sp. CMB-F115
Project description:Chemical investigations of Penicillium sp. CMB-STF067 is based on both the antibacterial property of its extract and the Global Natural Product Social (GNPS) molecular networking analysis of 176 soil-associated fungi, guided the isolation of 4-new xanthoquinodins, jugiones A-D.
Project description:Chemical investigations of Penicillium sp. CMB-STF067 is based on both the antibacterial property of its extract and the Global Natural Product Social (GNPS) molecular networking analysis of 176 soil-associated fungi, guided the isolation of 4-new xanthoquinodins, jugiones A-D.
Project description:Social experience influences multiple behaviors of many animal species, including aggression. Social isolation often increases aggressiveness. To investigater the molecular basis of social influences on aggressiveness, we performed comparative gene expression profiling on heads from 6-day-old, single-housed, more aggressive and group-housed, less aggressive male flies. Keywords: social experience
Project description:The lateral habenula (LHb) is an essential hub brain region modulating the monoamine system such as dopamine, serotonin. Hyperactivity of LHb has implications for psychiatric disorders such as depression, anxiety, and schizophrenia, which are commonly associated with social dysfunction. However, the role of LHb in social behavior has remained elusive. Here, we find that experiencing acute social isolation affects synaptic function in LHb and social behavior. After acute social isolation, long-term depression (LTD) in LHb is impaired and rescued by activating the 5-HT4 receptor (5-HT4R). Indeed, Htr4 expression in LHb is up-regulated following acute social isolation. Finally, acute social isolation enhances the social preference for familiars such as housing-mates to stranger conspecifics. Consistent with electrophysiological results, pharmacological activation of 5-HT4R in LHb restored innate social preference. These results suggest that acute social isolation influences social decisions with 5-HT4R-dependent synaptic modification in LHb.
Project description:Social isolation poses a severe mental and physiological burden on humans. Most animal models that investigate this effect are based on prolonged isolation, which does not mimic the milder conditions experienced by people in the real world. Here we show that in the medial amygdala, a brain structure that is crucial for social memory, acute social isolation causes social memory loss and significant changes in specific mRNAs and proteins.
Project description:Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation.