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GNPS - Shotgun metabolomics analysis of Hungarian Tokaji wines

ABSTRACT: Hungarian Tokaji "aszu" and "furmint" wines were analyzed by LC-MS/MS in order to identify the molecular composition of the wines and to found compounds with potential health benefits.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Vitis Vinifera (ncbitaxon:29760)

SUBMITTER: Gergo Kallo

PROVIDER: MSV000085599 | GNPS | Wed Jun 17 04:28:00 BST 2020

REPOSITORIES: GNPS

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Publications

Compounds with Antiviral, Anti-Inflammatory and Anticancer Activity Identified in Wine from Hungary's Tokaj Region via High Resolution Mass Spectrometry and Bioinformatics Analyses.

Kalló Gergő G Kunkli Balázs B Győri Zoltán Z Szilvássy Zoltán Z Csősz Éva É Tőzsér József J

International journal of molecular sciences 20201215 24

(1) Background: Wine contains a variety of molecules with potential beneficial effects on human health. Our aim was to examine the wine components with high-resolution mass spectrometry including high-resolution tandem mass spectrometry in two wine types made from grapes with or without the fungus <i>Botrytis cinerea</i>, or "noble rot". (2) For LC-MS/MS analysis, 12 wine samples (7 without and 5 with noble rotting) from 4 different wineries were used and wine components were identified and quan ...[more]

PMID: 33334025

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Shotgun metabolomics analysis of Hungarian Tokaji wines

Project description:Hungarian Tokaji "aszu" and "furmint" wines were analyzed by LC-MS/MS in order to identify the molecular composition of the wines and to found compounds with potential health benefits.

2020-06-17 | MSV000085599 | MassIVE

Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

2011-05-18 | GSE23610 | GEO

Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

Project description:Traditional Chinese medicines (TCM), usually composed of a mixture of components, may simultaneously target multiple genes/pathways and thus achieve superior efficacy for complex diseases such as cancer. To identify novel mechanisms of action and potential health benefits for a TCM formula Si-Wu-Tang (SWT) widely used for womenâs health, we obtained the DNA microarray expression profiles for SWT, its active component ferulic acid, and estradiol in human breast cancer cell line MCF-7 and analyzed the gene expression signatures associated with each treatment using the âConnectivity Mapâ (cMAP). This study indicates that DNA microarray profiling analysis and cMAP data mining provide a powerful approach to discover unknown mechanisms of actions and identify potential new health benefits for TCM. We profiled the gene expression of MCF-7 cell lines to SWT, its active component FA, as well as estradiol using Affymetrix human genome U133 plus 2.0 arrays. The data set includes profiles for 24 samples, divided into eight groups of treatment: 0.001% DMSO used as the vehicle control (C), 0.1 ÂµM estradiol (EM), FA at three concentrations (0.1, 1, and 10 ÂµM) (FL, FM and FH) and SWT at three concentrations (0.0256, 0.256, and 2.56 mg/ml) (SL, SM and SH). For each treatment group, 3 biological replicates were included, resulting in 24 (8 groups Ã 3 replicates/group) RNA samples.

2011-05-18 | E-GEOD-23610 | biostudies-arrayexpress

Transcriptional and proteomic insights into phytotoxic activity of interspecific potato hybrids with low glycoalkaloid contents.

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Expression data from peripheral blood mononuclear cells in multiple sclerosis patients and controls

Project description:Multiple sclerosis (MS) is a neurodegenerative disease with a presumed autoimmune component. Expression profiling in immune cells can therefore be used in order to identify genes and pathways involved in MS pathogenesis. We conducted a genome-wide expression study in peripheral blood mononuclear cells (PBMC) from 12 MS patients and 15 controls in order to identify differentially expressed genes and pathways in MS.

2011-07-01 | GSE21942 | GEO

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