Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS-Metabolomics investigation of Carfilzomib's effects on renal function

ABSTRACT: Carfilzomib is anti-neoplastic agent indicated for multiple myeloma. The drug has been associated with heart toxicity with hypertension being the most common one. As the proper renal function plays crucial role in blood pressure regulation, this study investigates Carfilzomib's effects on kidneys. A targeted-metabolomics based methodology has been implemented using an in-house metabolites data base.

INSTRUMENT(S): Bruker maxis impact QTOFMS

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Panagiotis Efentakis E.Gikas N. Thomaidis Ioanna Andreadou Ioanna Barla

PROVIDER: MSV000089596 | GNPS | Fri Jun 03 05:57:00 BST 2022

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

Project description:Endothelial ERK1/2 pathway plays a crucial role in maintenance of endothelial homeostasis. Its suppression results in activation of TGFΒ signaling, leading to hypertension, renal failure, fibrosis and sudden death, findings similar to those observed in patients treated with anti-VEGF agents.

2019-05-07 | GSE130737 | GEO

The effect of serum from children with nephrotic syndrome on transcriptome of human immortalized podocytes cultured in vitro

Project description:Nephrotic syndrome (NS) is an unfavorable disease with heterogeneous causes and variable prognosis. One of the clinically crucial prognostic feature is the response to initial glucocorticoid treatment. Whereas in some children with steroid-sensitive nephrotic syndrome (SSNS) the treatment may induce long-term remission of the disease, steroid-resistant cases (SRNS) are at risk of renal failure requiring renal replacement therapy. The aim of this project was to explore whether sera from children with the two main clinically defined types of NS induce changes in transcriptome of in-vitro cultures of immortalized human podocytes. After 3 days of culture, total RNA was isolated and then library from polyadenylated RNA was prepared and RNA sequencing was performed. Log2 (fold-changes) were calculated to describe differential gene expression. Within the Reactome online tool, Camera methodology was implemented to identify functionally linked gene groups (pathways) that could distinguish the two patient groups. Significant transcriptome differences were found between samples from children with SSNS and SRNS. This may help to reveal the molecular mechanisms of the disease and open up for an effective individualized treatment.

2022-10-14 | GSE215231 | GEO

Expression data from mouse tissue Angiotensin II treated for 0, 1, 3, 7 days

Project description:Angiotensin II (Ang II) mediated signaling plays a key role in the development of hypertension associated target organ damages. However, the gene expression changes regulated by Ang II in the early stage of acute cerebral, cardiac, renal, vascular injury remain unclear. we investigated Ang II–mediated gene expression alteration associated with the development of early cerebral, cardiac, renal, vascular injury by microarray assay in a mouse model.

2017-10-19 | GSE105114 | GEO

Expression data from mouse tissue Angiotensin II treated for 0,1,3,7days

2014-07-16 | GSE59437 | GEO

Project description:Spatial methodology for Understanding Honey Bee Toxicity

| PRJNA1118276 | ENA

Glis3 plays a crucial role in spermatogenesis

Project description:Glis3 plays a crucial role in spermatogenesis

| PRJNA287827 | ENA

Beta cell 5’-shifted isomiRs are candidate regulatory hubs in type 2 diabetes

Project description:We performed deep sequencing of small RNA from mouse insulinoma (MIN6) cells cultured in 25mM glucose. We then developed and implemented an in-house short-read mapping strategy to analyze isomiR diversity.

2013-09-10 | GSE44262 | GEO

Oxysterol Sensing through GPR183 Triggers Endothelial Senescence and Cardio-renal Injuries via Altering Circadian Signaling in Hypertension

Project description:Background: Despite endothelial dysfunction being considered as the initial step of the development of hypertension and associated cardio-renal syndromes, effective therapeutic strategies to prevent endothelial injuries are still lacking. GPR183 is a recently identified GPCR for oxysterols and hydroxylated metabolites of cholesterol. Here, we explored a previously unappreciated role of GPR183 in hypertension and age-related cardio-renal injuries. Methods and results: Mice were treated with DOCA/Salt or AngII to induce hypertension. we found that endothelial GPR183 was significantly induced in aged or hypertensive mice, which was further confirmed in renal biopsies from elderly people or subjects with hypertensive nephropathy. In addition, we found that endothelial-specific GPR183 deletion markedly ameliorated endothelial senescence and cardio-renal injuries in hypertensive mice. Mechanistically, we found that GPR183 disrupted circadian signaling by inhibiting PER1 expression, thereby facilitating endothelial senescence and dysfunction through the cAMP/PKA/CREB signaling pathway. Importantly, pharmacological inhibition of the oxysterol-GPR183 axis by NIBR189 or Clotrimazole ameliorated endothelial senescence and cardio-renal injuries in hypertensive mice. Conclusions: GPR183 is an attractive therapeutic target for hypertension and age-related diseases. Targeting GPR183 could provide novel strategies for managing hypertension and its associated cardio-renal injuries.

2024-06-23 | GSE270175 | GEO

Expression data from mouse kidney

Project description:Hypertension is a major risk factor for chronic kidney disease (CKD) and renal inflammation is an integral part in this pathology. Hydrogen sulfide (H2S) has been shown to mitigate renal damage through reduction in blood pressure and reactive oxygen species; however, the exact mechanisms are not clear. While several studies have underlined the role of epigenetics in renal inflammation and dysfunction, the mechanisms through which epigenetic regulators play role in hypertension are not well defined. We used microarrays to detail the global programme of gene expression underlying hypertension in the kidney and how hydrogen sulfide supplementation alleviates these effects.

2016-12-23 | GSE92857 | GEO

Mus musculus

Project description:Glis3 plays a crucial role in spermatogenesis [923]

| PRJNA287830 | ENA