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GNPS - Lipidomics of mice with overexpression of citrate transporters SLC13A5 and SLC25A1

ABSTRACT: This data set contains lipidomics data presented in manuscript "Overexpression of the citrate transporters SLC13A5 and SLC25A1 in the mouse elicit different metabolic responses and phenotypes".

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Josh J. Coon

PROVIDER: MSV000090972 | GNPS | Tue Dec 27 12:56:00 GMT 2022

REPOSITORIES: GNPS

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The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse.

Fernandez-Fuente Gonzalo G Overmyer Katherine A KA Lawton Alexis J AJ Kasza Ildiko I Shapiro Samantha L SL Gallego-Muñoz Patricia P Coon Joshua J JJ Denu John M JM Alexander Caroline M CM Puglielli Luigi L

Communications biology 20230909 1

Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which can then be exported to the endoplasmic reticulum (ER) by SLC33A1. Here, we report the generation of mice with systemic overexpression (sTg) of SLC25A1 or SLC13A5. Both animals displayed increased cytosolic levels of citrate and acetyl-CoA; however, SLC13A5 sTg mice developed a progeria-like phenotype with premature de ...[more]

PMID: 37689798

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