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Phosphoproteome profiling of mouse liver during normal aging

ABSTRACT: Totally, fourteen two-month-old mice were used in the young group and ten eighteen-month-old mice were used in the old group. Their livers were detached for phosphoproteome analysis.

ORGANISM(S): Mus Musculus

SUBMITTER: Juntao Yang

PROVIDER: PXD024270 | iProX | Sun Feb 21 00:00:00 GMT 2021

REPOSITORIES: iProX

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Phosphoproteome profiling of mouse liver during normal aging.

Liu Jiang-Feng JF Wu Yue Y Yang Ye-Hong YH Wu Song-Feng SF Liu Shu S Xu Ping P Yang Jun-Tao JT

Proteome science 20220805 1

<h4>Background</h4>Aging is a complex biological process accompanied by a time-dependent functional decline that affects most living organisms. Omics studies help to comprehensively understand the mechanism of aging and discover potential intervention methods. Old mice are frequently obese with a fatty liver.<h4>Methods</h4>We applied mass spectrometry-based phosphoproteomics to obtain a global phosphorylation profile of the liver in mice aged 2 or 18 months. MaxQuant was used for quantitative a ...[more]

PMID: 35932011

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