Proteomics

Dataset Information

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Luminal cerebrovascular proteomic changes during aging


ABSTRACT: The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis. However, during aging and neurodegenerative disease, the BBB undergoes numerous molecular changes that can promote inflammation and disease pathogenesis. In this work, we profile the luminal (blood-facing) surface of the cerebral vasculature using sulfo-NHS-biotin to tag and enrich proteins from acutely isolate microvessedls from young (3-month-old) and aged (21-month-old) mice.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Sophia Shi  

LAB HEAD: Tony Wyss-Coray

PROVIDER: PXD043964 | Pride | 2024-12-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Aged1_LP.raw Raw
Aged2_LP.raw Raw
Aged3_LP.raw Raw
Aged4_LP.raw Raw
Aged5_LP.raw Raw
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