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Identification of blood MHC-binding peptides in mice after Brucella infection

ABSTRACT: We infected mice with Brucella, took mouse blood 6 days after infection, MHC binding antigenic peptides were collected by immunoprecipitation method and verified by mass spectrometry

ORGANISM(S): Mus Musculus

SUBMITTER: Yufei Wang

PROVIDER: PXD032855 | iProX | Sun Mar 27 00:00:00 GMT 2022

REPOSITORIES: iProX

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Identification of potential antigenic peptides of Brucella through proteome and peptidome.

Pei Meijuan M Dong Ao A Ma Xueping X Li Shulei S Guo Yan Y Li Menglan M Wang Zhenghui Z Wang Hengliang H Zhu Li L Pan Chao C Wang Yufei Y

Veterinary medicine and science 20221230 1

<h4>Background</h4>Brucellosis, caused by Brucella spp., is a major zoonotic public health threat. Although several Brucella vaccines have been demonstrated for use in animals, Brucella spp. can cause human infection and to date, there are no human-use vaccines licensed by any agency. Recently, methods in vaccine informatics have made major breakthroughs in peptide-based epitopes, opening up a new avenue of vaccine development.<h4>Objectives</h4>The purpose of this article was to identify potent ...[more]

PMID: 36583994

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