Dataset Information
ProSeAM SILAC MS screening for METTL9 substrates
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Yoichi Shinkai
PROVIDER: PXD016823 | JPOST Repository | Thu Nov 19 00:00:00 GMT 2020
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 181026_QE2_151_Shimazu_A.raw | Raw | |||
| 181026_QE2_151_Shimazu_B.raw | Raw | |||
| 181026_QE2_151_Shimazu_Result.xlsx | Xlsx |
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Publications
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Nature communications 20210209 1
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mouse and human proteomes. METTL9-catalyzed methylation requires a His-x-His (HxH) motif, where "x" is ...[more]
