Dataset Information
ProSeAM SILAC MS screening for METTL18 substrates
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Yoichi Shinkai
PROVIDER: PXD026813 | JPOST Repository | Thu Jun 09 00:00:00 BST 2022
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 190626_QE_065_Shimazu_A.raw | Raw | |||
| 190913_QE_159_Shimazu_A.raw | Raw | |||
| METTL18-ProSeAM-SILAC.xlsx | Xlsx |
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Publications
METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
eLife 20220608
Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a methylation substrate. However, a limited number of enzymes responsible for this modification have been reported. Moreover, the biological role of histidine methylation has remained poorly understood to date. Here, we report that human METTL18 is a histidine methyltransferase for the ribosomal protein RPL3 and that the modification specifically slows ribosome traversal on Tyr codons, allowing ...[more]
