Dataset Information
Time course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus Rattus (black Rat)
SUBMITTER: Janne Lehtiö
PROVIDER: PXD020851 | JPOST Repository | Tue Aug 18 00:00:00 BST 2020
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 100702_VR_Palm_fr_11.raw | Raw | |||
| 100702_VR_Palm_fr_12.raw | Raw | |||
| 100709_VR_Palm_60min_Fr_13.raw | Raw | |||
| 100709_VR_Palm_60min_Fr_14.raw | Raw | |||
| 100709_VR_Palm_60min_Fr_15.raw | Raw |
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Publications
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.
BMC genomics 20200826 1
<h4>Background</h4>Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cell failure observed in type 2 diabetes. In order to map the β-cell response to lipotoxicity, we combined RNA-sequencing of palmitate-treated human islets with iTRAQ proteomics of insulin-secreting INS-1 ...[more]
