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Hidden Proteome of Synaptic Vesicles in the Mammalian Brain

ABSTRACT: current synapse proteomics are restricted to “average” composition of abundant synaptic proteins. Here we performed a subcellular proteomic workflow that could identify and quantify the deep proteome of synaptic vesicles purified from rat whole brain, including previously missing proteins present in a small percentage of central synapses. This synaptic vesicle proteome newly detected many proteins of physiological and pathological relevance particularly in low abundance range, thus providing a resource for future investigations on diversified synaptic functions and neuronal dysfunctions. Raw data from 3 replicates of synaptosomes (P2') and 3 replicates of SV are deposited here. Each replicate coming from 24 fractions from a peptide fractionation step in the workflow.

ORGANISM(S): Rattus Norvegicus Albus

SUBMITTER: Zacharie Taoufiq

PROVIDER: PXD021549 | JPOST Repository | Thu Dec 31 00:00:00 GMT 2020

REPOSITORIES: jPOST

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			Action	DRS
	P2-18-1.raw	Raw
	P2-18-2.raw	Raw
	P2-18-3.raw	Raw
	P2-19-1.raw	Raw
	P2-19-2.raw	Raw

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