Proteomics

Dataset Information

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HLA class I ligandome of colon cancer tissues for lncRNA antigen identification

ABSTRACT: MS data of HLA class I ligandome of human colon cancer tissues

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takayuki Kanaseki 

PROVIDER: PXD024533 | JPOST Repository | Mon Sep 27 00:00:00 BST 2021

REPOSITORIES: jPOST

Json Xml

Dataset's files

Source:
Action DRS
ST419_CRC71_A24.raw Raw
ST419_CRC71_A24_PD.mgf Mgf
ST503_Colo320_A24.raw Raw
ST503_Colo320_A24_PD.mgf Mgf
ST544_CRC117_A24.raw Raw
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Publications

CD8<sup>+</sup> T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA <i>PVT1</i>.

Kikuchi Yasuhiro Y   Tokita Serina S   Hirama Tomomi T   Kochin Vitaly V   Nakatsugawa Munehide M   Shinkawa Tomoyo T   Hirohashi Yoshihiko Y   Tsukahara Tomohide T   Hata Fumitake F   Takemasa Ichiro I   Sato Noriyuki N   Kanaseki Takayuki T   Torigoe Toshihiko T  

Cancer immunology research 20210825 11

CD8<sup>+</sup> T cells recognize peptides displayed by HLA class I molecules on cell surfaces, monitoring pathologic conditions such as cancer. Advances in proteogenomic analysis of HLA ligandomes have demonstrated that cells present a subset of cryptic peptides derived from noncoding regions of the genome; however, the roles of cryptic HLA ligands in tumor immunity remain unknown. In the current study, we comprehensively and quantitatively investigated the HLA class I ligandome of a set of hum  ...[more]