Dataset Information
HLA-I and HLA-II peptidomes for NESSIE
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Takayuki Kanaseki
PROVIDER: PXD047303 | JPOST Repository | Thu Aug 08 00:00:00 BST 2024
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ST679_CRC135normal_A2_1.mgf | Mgf | |||
| ST679_CRC135normal_A2_1.raw | Raw | |||
| ST679_CRC135normal_A2_2.mgf | Mgf | |||
| ST679_CRC135normal_A2_2.raw | Raw | |||
| ST679_CRC135normal_A2_3.mgf | Mgf |
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Publications
Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes.
Science advances 20240918 38
Neoantigens arising from somatic mutations are tumor specific and induce antitumor host T cell responses. However, their sequences are individual specific and need to be identified for each patient for therapeutic applications. Here, we present a proteogenomic approach for neoantigen identification, named Neoantigen Selection using a Surrogate Immunopeptidome (NESSIE). This approach uses an autologous wild-type immunopeptidome as a surrogate for the tumor immunopeptidome and allows human leukocy ...[more]
