Proteomics

Dataset Information

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Characterization of HLA-A*02:01 MHC Immunopeptide Antigens Enhanced by Ultraviolet Photodissociation Mass Spectrometry


ABSTRACT: Triplicate results for 193 nm UVPD, HCD, and EThcD of a mixture of 157 synthetic peptide mixture, and 193 nm UVPD, HCD, and EThcD of BB7.2 and W6/32 immunoprecipitations

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jennifer Brodbelt 

PROVIDER: PXD027830 | JPOST Repository | Fri Aug 13 00:00:00 BST 2021

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
157mix_UVPD4p3mJ_2.raw Raw
157mix_UVPD4p3mJ_3.raw Raw
BB72_EThcD_1.raw Raw
BB72_EThcD_2.raw Raw
BB72_EThcD_3.raw Raw
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Publications

Characterization of HLA-A*02:01 MHC Immunopeptide Antigens Enhanced by Ultraviolet Photodissociation Mass Spectrometry.

Watts Eleanor E   Potts Gregory K GK   Ready Damien B DB   George Thompson Alayna M AM   Lee Janice J   Escobar Edwin E EE   Patterson Melanie J MJ   Brodbelt Jennifer S JS  

Analytical chemistry 20210923 39


Identifying major histocompatibility complex (MHC) class I immunopeptide antigens represents a key step in the development of immune-based targeted therapeutics and vaccines. However, the complete characterization of these antigens by tandem mass spectrometry remains challenging due to their short sequence length, high degree of hydrophobicity, and/or lack of sufficiently basic amino acids. This study seeks to address the potential for 193 nm ultraviolet photodissociation (UVPD) to improve the a  ...[more]

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