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MHC class I ligandome of cells treated with palladium

ABSTRACT: MHC class I ligandome analysis of mouse dendritic cells treated with palladium

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Takayuki Kanaseki

PROVIDER: PXD028795 | JPOST Repository | Thu Dec 16 00:00:00 GMT 2021

REPOSITORIES: jPOST

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			Action	DRS
	ST402_03_DC24_LPS_Db_1.mgf	Mgf
	ST402_03_DC24_LPS_Db_1.raw	Raw
	ST402_03_DC24_LPS_Db_2.mgf	Mgf
	ST402_03_DC24_LPS_Db_2.raw	Raw
	ST402_03_DC24_LPS_Db_3.mgf	Mgf

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Publications

Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity.

Ito Koyu K Kanaseki Takayuki T Tokita Serina S Torigoe Toshihiko T Hirasawa Noriyasu N Ogasawara Kouetsu K

Frontiers in immunology 20211223

Palladium (Pd) is a widely used metal and extremely important biomaterial for the reconstruction of occlusions during dental restorations. However, metallic biomaterials can cause serious allergic reactions, such as Pd-related oral mucositis seen in dentistry. Metal allergy is categorized as a type IV allergy and we demonstrated that CD8 T cells play an important role in Pd allergy previously. As TCR of CD8 T cells recognizes MHC class I/peptide complex, the antigen specificity to this complex s ...[more]

PMID: 35003059

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