Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Shintaro Seto
PROVIDER: PXD030088 | JPOST Repository | Tue Sep 06 00:00:00 BST 2022
REPOSITORIES: jPOST
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Frontiers in cellular and infection microbiology 20220927
Infection with <i>Mycobacterium tuberculosis</i> leads to the development of tuberculosis (TB) with the formation of granulomatous lesions. Foamy macrophages (FM) are a hallmark of TB granulomas, because they provide the primary platform of <i>M. tuberculosis</i> proliferation and the main source of caseous necrosis. In this study, we applied spatial multiomic profiling to identify the signatures of FM within the necrotic granulomas developed in a mouse model resembling human TB histopathology. ...[more]