Proteomics

Dataset Information

0

Proteome analysis of GCN1 CKO mouse inguinal white adipose tissue (iWAT)

ABSTRACT: Tamoxifen-inducible conditional knockout (CKO) mice were generated to explore the function of Gcn1 in adult mice using the Cre/loxP system. To analyze the function of GCN1 in the inguinal white adipose tissue (iWAT), we compared the whole cell proteome of eWAT harvested from GCN1 CKO mice with that of wild-type mice.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Ken Itoh 

PROVIDER: PXD030516 | JPOST Repository | Sun Mar 31 00:00:00 GMT 2024

REPOSITORIES: jPOST

Json Xml

Dataset's files

Source:
Action DRS
210810_Liu_iWAT_1083_IDA.wiff.scan Wiff
210810_Liu_iWAT_1083_SWATH.wiff.scan Wiff
210810_Liu_iWAT_1084_IDA.wiff.scan Wiff
210810_Liu_iWAT_1084_SWATH.wiff.scan Wiff
210810_Liu_iWAT_1116_IDA.wiff.scan Wiff
Items per page:
1 - 5 of 20
altmetric image

Publications

Inducible Systemic <i>Gcn1</i> Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu Jun J   Kasai Shuya S   Tatara Yota Y   Yamazaki Hiromi H   Mimura Junsei J   Mizuno Seiya S   Sugiyama Fumihiro F   Takahashi Satoru S   Sato Tsubasa T   Ozaki Taku T   Tanji Kunikazu K   Wakabayashi Koichi K   Maeda Hayato H   Mizukami Hiroki H   Shinkai Yasuhiro Y   Kumagai Yoshito Y   Tomita Hirofumi H   Itoh Ken K  

International journal of molecular sciences 20220316 6

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that <i>Gcn1</i> mutant mice lacking the GCN2-binding domain suffer from growth retardation and postnatal lethality via GCN2-independent mechanisms, while <i>Gcn1</i>-null mice die early in embryonic development. In this study, we explored the role of GCN1 in adult mice by generating tamoxifen-inducible conditional knoc  ...[more]

Similar Datasets

Proteomics Proteome analysis of GCN1 CKO mouse duodenum
2024-03-31 | PXD030517 | JPOST Repository
Proteomics Proteome analysis of GCN1 CKO mouse jejunum
2022-08-29 | PXD030519 | JPOST Repository
Proteomics Proteome analysis of GCN1 CKO mouse liver
2023-04-01 | PXD030514 | JPOST Repository
Proteomics Proteome analysis of GCN1 CKO mouse ileum
2024-03-31 | PXD030518 | JPOST Repository
Transcriptomics Next Generation Sequencing of Loxp (Rxratm1Krc/J,Rxra loxP), Hetero(Nex-cre;Rxratm1Krc/J,Rxra cKO-Het) and cKO (Nex-cre;Rxratm1Krc/J,Rxra cKO) mouse Transcriptomes
2019-09-04 | GSE136788 | GEO
Transcriptomics Genome-wide analysis of gene expression of Flk1Cre;ETV2 CKO mouse yolk sacs.
2014-11-17 | E-GEOD-51407 | biostudies-arrayexpress
Proteomics Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
2022-03-14 | PXD031136 | Pride
Transcriptomics Mechanisms of stop codon readthrough mitigation reveal principles of GCN1 mediated translational quality control
2023-05-15 | GSE214396 | GEO
Genomics Next Generation Sequencing of Loxp (Rxratm1Krc/J,Rxra loxP), Hetero(Nex-cre Rxratm1Krc/J,Rxra cKO-Het) and cKO (Nex-cre Rxratm1Krc/J,Rxra cKO) mouse Transcriptomes
| PRJNA563673 | ENA
Transcriptomics Gene expression profiling of Smad1/5 cKO and Acvr2a cKO mice
2021-04-23 | GSE152675 | GEO