Proteomics

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Proteome analysis of GCN1 CKO mouse inguinal white adipose tissue (iWAT)

ABSTRACT: Tamoxifen-inducible conditional knockout (CKO) mice were generated to explore the function of Gcn1 in adult mice using the Cre/loxP system. To analyze the function of GCN1 in the inguinal white adipose tissue (iWAT), we compared the whole cell proteome of eWAT harvested from GCN1 CKO mice with that of wild-type mice.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Ken Itoh 

PROVIDER: PXD030516 | JPOST Repository | Sun Mar 31 00:00:00 GMT 2024

REPOSITORIES: jPOST

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210810_Liu_iWAT_1083_IDA.wiff.scan Wiff
210810_Liu_iWAT_1083_SWATH.wiff.scan Wiff
210810_Liu_iWAT_1084_IDA.wiff.scan Wiff
210810_Liu_iWAT_1084_SWATH.wiff.scan Wiff
210810_Liu_iWAT_1116_IDA.wiff.scan Wiff
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Publications

Inducible Systemic <i>Gcn1</i> Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.

Liu Jun J   Kasai Shuya S   Tatara Yota Y   Yamazaki Hiromi H   Mimura Junsei J   Mizuno Seiya S   Sugiyama Fumihiro F   Takahashi Satoru S   Sato Tsubasa T   Ozaki Taku T   Tanji Kunikazu K   Wakabayashi Koichi K   Maeda Hayato H   Mizukami Hiroki H   Shinkai Yasuhiro Y   Kumagai Yoshito Y   Tomita Hirofumi H   Itoh Ken K  

International journal of molecular sciences 20220316 6

GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that <i>Gcn1</i> mutant mice lacking the GCN2-binding domain suffer from growth retardation and postnatal lethality via GCN2-independent mechanisms, while <i>Gcn1</i>-null mice die early in embryonic development. In this study, we explored the role of GCN1 in adult mice by generating tamoxifen-inducible conditional knoc  ...[more]

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