Dataset Information

O-glycoproteomic datasets on the serum samples from healthy individuals

ABSTRACT: Clinical O-glycoproteomics for the development of diagnostic marker for colorectal cancer based on changes in O-glycosylation of serum protein.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Daisuke Takakura

PROVIDER: PXD035280 | JPOST Repository | Thu Jul 13 00:00:00 BST 2023

REPOSITORIES: jPOST

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Dataset's files

Source:

			Action	DRS
	Serum_Oglycopep_Healthy%20Control%2010_NCE27.raw	Raw
	Serum_Oglycopep_Healthy%20Control%2010_NCE35.raw	Raw
	Serum_Oglycopep_Healthy%20Control%201_NCE27.raw	Raw
	Serum_Oglycopep_Healthy%20Control%201_NCE35.raw	Raw
	Serum_Oglycopep_Healthy%20Control%202_NCE27.raw	Raw

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Publications

Targeted O-glycoproteomics for the development of diagnostic markers for advanced colorectal cancer.

Takakura Daisuke D Ohashi Shoko S Kobayashi Noritoshi N Tokuhisa Motohiko M Ichikawa Yasushi Y Kawasaki Nana N

Frontiers in oncology 20230209

Aberrant glycosylation is a prominent feature of cancer, that can be used as targets to improve the existing cancer biomarkers, and help to assess metastasis risks, and therapeutic effects. We developed a targeted O-glycoproteomics method using serum specimens, and evaluated its utility in identifying advanced colorectal cancer (CRC) markers. To this end, we combined consecutive lectin affinity purification using <i>Maclura pomifera</i> lectin (MPL), jacalin, and <i>Sambucus nigra</i> lectin, wh ...[more]

PMID: 36845686

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