Dataset Information

Human brain glycoproteomic network alterations in Alzheimer’s disease

ABSTRACT: We performed a large-scale, site-specific N-glycoproteome profiling study of human Alzheimer’s disease (AD) and control brains using mass spectrometry–based quantitative N-glycoproteomics. The study provided a system-level view of human brain N-glycoproteins and in vivo N-glycosylation sites and identified disease signatures of altered N-glycopeptides, N-glycoproteins, and N-glycosylation site occupancy in AD. Glycoproteomic data-driven network analysis showed 13 modules of co-regulated N-glycopeptides/glycoproteins, 6 of which are associated with AD phenotypes.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: QI ZHANG

LAB HEAD: Lian Li

PROVIDER: PXD037229 | Pride | 2022-11-02

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Emory_Glycosite_Alzheimer_1.raw	Raw
	Emory_Glycosite_Alzheimer_2.raw	Raw
	Emory_Glycosite_Alzheimer_3.raw	Raw
	Emory_Glycosite_Alzheimer_4.raw	Raw
	Emory_Glycosite_Alzheimer_5.raw	Raw

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Publications

Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease.

Zhang Qi Q Ma Cheng C Chin Lih-Shen LS Li Lian L

Science advances 20201002 40

Protein N-glycosylation plays critical roles in controlling brain function, but little is known about human brain N-glycoproteome and its alterations in Alzheimer's disease (AD). Here, we report the first, large-scale, site-specific N-glycoproteome profiling study of human AD and control brains using mass spectrometry-based quantitative N-glycoproteomics. The study provided a system-level view of human brain N-glycoproteins and in vivo N-glycosylation sites and identified disease signatures of a ...[more]

PMID: 33008897

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