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Mutated in Colorectal Cancer (MCC): A Novel Centrosomal Protein Involved in Intestinal Homeostasis and Disease

ABSTRACT: Mutated in Colorectal Cancer (MCC) is a candidate tumor suppressor gene reported to be somatically mutated in the inherited colorectal cancer (CRC) syndrome Familial Adenomatous Polyposis. Additionally, MCC deletion and loss-ofheterozygosity have also been reported as a common event in human CRC. However,to date, more than 28 years since its discovery, the mechanisms by which MCC contributes to intestinal cancer development as well as its function during normal intestinal tissue homeostasis remain unknown.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Ray Dunn

PROVIDER: PXD035614 | JPOST Repository | Sat Jul 29 00:00:00 BST 2023

REPOSITORIES: jPOST

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	20190911_RD_S1.raw	Raw
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