Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Tetsuya Okajima
PROVIDER: PXD035703 | JPOST Repository | Sat Jul 27 00:00:00 BST 2024
REPOSITORIES: jPOST
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Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation.
Zhang Ailing A Tsukamoto Yohei Y Takeuchi Hideyuki H Nishiwaki Kimitoshi K Tashima Yuko Y Okajima Tetsuya T
Analytical biochemistry 20220905
The Notch pathway represents evolutionarily conserved intercellular signaling essential for cell-to-cell communication during development. Dysregulation of Notch signaling has been implicated in various diseases, and its control represents a potential cancer treatment strategy. Notch signaling is initiated by the interaction of NOTCH receptors with their ligands on neighboring cells. Therefore, the truncated NOTCH ectodomain, composed mainly of tandem repeats of epidermal growth factor-like (EGF ...[more]
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