Proteomics

Dataset Information

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Proteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary Adenoma


ABSTRACT: Gene alteration analysis on 121 GH-producing pituitary adenomas and non-target proteomics analysis with RNA sequencing analysis on 45 non-functioning pituitary adenomas (NFPAs) and 60 growth hormone (GH)-producing pituitary adenomas were performed, and integrated these results with the clinical characteristics of acromegaly. We attempted to identify key players involved in shaping the clinical features of acromegaly, especially those related to treatment efficacy. This project revealed the importance of GNAS mutations in terms of clinical and biochemical characteristics and identified novel molecules that may be involved in the responsiveness to medical treatment.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Tomoaki Tanaka 

PROVIDER: PXD036604 | JPOST Repository | Thu Nov 24 00:00:00 GMT 2022

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
GH001.raw Raw
GH002.raw Raw
GH003.raw Raw
GH004.raw Raw
GH005.raw Raw
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