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TMT-16plex analysis of 25 individual human liver microsome and cytosol

ABSTRACT: Comprehensive proteomic analysis for human liver microsome and human liver cytosol from 25 individual donors focusing on drug metabolising enzymes with relative quantification with TMTpro.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takuma Katayama

PROVIDER: PXD038055 | JPOST Repository | Thu Nov 09 00:00:00 GMT 2023

REPOSITORIES: jPOST

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			Action	DRS
	201027_Kanazawa_TMT16plex_hlm1_F01.raw	Raw
	201027_Kanazawa_TMT16plex_hlm1_F02.raw	Raw
	201027_Kanazawa_TMT16plex_hlm1_F03.raw	Raw
	201027_Kanazawa_TMT16plex_hlm1_F04.raw	Raw
	201027_Kanazawa_TMT16plex_hlm1_F05.raw	Raw

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Publications

Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern.

Kudo Takashi T Hashiba Shiori S Fukami Tatsuki T Morinaga Gaku G Nishiyama Kotaro K Ichida Hiroyuki H Hirosawa Keiya K Matsui Akiko A Ishiguro Naoki N Nakajima Miki M

Drug metabolism and disposition: the biological fate of chemicals 20230508 7

To predict the variation of pharmacological or toxicological effect caused by pharmacokinetic variance, it is important to be able to detect previously unknown and unsuspected enzymes involved in drug metabolism. We investigated the use of proteomic correlation profiling (PCP) as a technique to identify the enzymes involved in metabolism of drugs of concern. By evaluating the metabolic activities of each enzyme (including isoforms of cytochrome P450, uridine 5' diphospho-glucuronosyltransferase, ...[more]

PMID: 37156625

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