Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Proteome characterization of the neoadjuvant clinical trial PROMIX

ABSTRACT: Proteome characterization of the neoadjuvant clinical trial PROMIX. https://www.clinicaltrials.gov/ct2/show/NCT00957125 Patients received six rounds of chemotherapy with epirubicin and docetaxel, and if PR or PD after the second course, bevacizumab.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Janne Lehtiö

PROVIDER: PXD039529 | JPOST Repository | Tue Mar 19 00:00:00 GMT 2024

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	PROMIX_20170504_set1_IPG3-10_fr13.raw	Raw
	PROMIX_20170504_set1_IPG3-10_fr14.raw	Raw
	PROMIX_20170504_set1_IPG3-10_fr15.raw	Raw
	PROMIX_20170504_set1_IPG3-10_fr16.raw	Raw
	PROMIX_20170504_set1_IPG3-10_fr17.raw	Raw

Items per page:

1 - 5 of 20

Similar Datasets

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in hepatocellular carcinoma

Project description:Hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth lethal cancer worldwide. We performed proteomic and metabolomic profiling of sera from 67 HCC patients who received pembrolizumab therapy and 15 healthy individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort containing 26 patients with resistance to PD-1 treatment and 23 patients with response to PD-1 treatment. The model was validated using a testing cohort containing 7 patients with resistance to PD-1 treatment and 6 patients with response to PD-1 treatment, 12 of which were correctly classified. Our analysis reveals the proteomic and metabolic features of HCC patients which correlated with PD1 antibody therapy and provide serum predictive markers for selection of patients with potential response to PD1 therapy.

2022-06-02 | PXD034263 |

Molecular characterization of two unrelated patients ABCB4 deletions

Project description:To allow acute characterization of ABCB4 locus constitutional deletion in two patients with cholelithiasis/cholestasis, an Agilent 2X400 array CGH was used. Goal was to obtain genomic rearrangements fine characterization in order to describe ABCB4 constitutional deletions. ABCB4 locus microdeletions characterization vs reference sample (pool of six normal control DNAs)

2011-10-04 | E-GEOD-28676 | biostudies-arrayexpress

Characterization of Unbranched Ubiquitin Tetramers by Combining Ultraviolet Photodissociation with Proton Transfer Charge Reduction Reactions

Project description:Characterization of six unbranched ubiquitin tetramers linked at various Lys using UVPD followed by PTCR

2024-06-16 | PXD043027 | JPOST Repository

Discovery and Characterization of Second-Generation BET Bromodomain Inhibitor RG6146

Project description:Discovery and Characterization of Second-Generation BET Bromodomain Inhibitor RG6146

| PRJNA837999 | ENA

EThcD-sceHCD-MS/MS-based Clinical N-glycoproteomics

Project description:Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy collisional dissociation (sceHCD), and higher-energy collision dissociation-product-dependent electron-transfer dissociation (HCD-pd-ETD) have emerged as valuable approaches for clinical glycoproteomics. However, each of them incurs some compromise, necessitating the performance comparisons when applied to the analysis of complex clinical samples (e.g., plasma, urine, cells, and tissue). Herein, we developed a hybrid mass spectrometry fragmentation method, EThcD-sceHCD, by combining EThcD and sceHCD. Moreover, we compared the performance of this method with those previous approaches (EThcD, sceHCD, HCD-pd-ETD, and sceHCD-pd-ETD) in the intact N-glycopeptide analysis, and determined its applicability for clinical N-glycoproteomic study.

2022-04-04 | PXD030288 | Pride

Clinical and molecular characterization of splenic diffuse red pulp lymphomas [Agilent]

Project description:Deep characterization of a large series of splenic diffuse red pulp lymphomas

2017-12-23 | GSE65060 | GEO

Molecular characterization of head and neck cancer cell model genomes

Project description:To provide full characterization of genome changes in six commonly used head and neck cancer cell lines. These data will serve as an excellent resource when designing future experiments that attempt to model HNSCC behaviour.

2010-06-26 | GSE16872 | GEO

In Vitro Characterization of A4573 Preclinical Radiation-Adapted Model for Ewing Sarcoma

Project description:Analysis of differentially expressed genes in wild type A4573 Ewing Sarcoma cells when compared to A4573 Ewing Sarcoma cells that received six 4 Gy fractions (cumulative dose of 24 Gy) of ionizing radiation (radiation-adapted cell line). The hypothesis tested being that repeated ionizing radiation exposure of modifies radiation therapy response in Ewing Sarcoma.

2017-05-10 | GSE98706 | GEO

Molecular characterization of head and neck cancer cell model genomes

2010-06-25 | E-GEOD-16872 | biostudies-arrayexpress

In Vitro Characterization of SK-ES1 Preclinical Radiation-Adapted Model for Ewing Sarcoma

Project description:Analysis of differentially expressed genes in wild type SK-ES1 Ewing Sarcoma cells when compared to SK-ES1 Ewing Sarcoma cells that received six 4 Gy fractions (cumulative dose of 24 Gy) of ionizing radiation (radiation-adapted cell line). The hypothesis tested being that repeated ionizing radiation exposure of modifies radiation therapy response in Ewing Sarcoma.

2017-05-10 | GSE98711 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data