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Shotgun proteomics of mouse oocytes

ABSTRACT: Shotgun mass spectrometric analysis of Cre control and CNOT7&8 KO GV oocytes

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Masaaki Oyama

PROVIDER: PXD039816 | JPOST Repository | Thu Sep 28 00:00:00 BST 2023

REPOSITORIES: jPOST

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			Action	DRS
	20210804_soeda_KO_FAIMS_180min_10ms_09.raw	Raw
	20210804_soeda_cre_FAIMS_180min_10ms_06.raw	Raw
	20210806_hata_20210804_soeda_KO.xlsx	Xlsx
	20210806_hata_20210804_soeda_cre.xlsx	Xlsx

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Publications

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

Soeda Shou S Oyama Masaaki M Kozuka-Hata Hiroko H Yamamoto Tadashi T

Development (Cambridge, England) 20231018 21

Control of mRNA poly(A) tails is essential for regulation of mRNA metabolism, specifically translation efficiency and mRNA stability. Gene expression in maturing oocytes relies largely on post-transcriptional regulation, as genes are transcriptionally silent during oocyte maturation. The CCR4-NOT complex is a major mammalian deadenylase, which regulates poly(A) tails of maternal mRNAs; however, the function of the CCR4-NOT complex in translational regulation has not been well understood. Here, w ...[more]

PMID: 37767629

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