Proteomics

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Changes in the astronaut serum proteome during prolonged spaceflight

ABSTRACT: The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative comprehensive proteome analysis performed with the data-independent acquisition method of mass spectrometry (DIA-MS). DIA-MS successfully identified 624 non-redundant proteins in sera and further quantitative analysis for each sampling point provided information on serum protein profiles closely related to several time points before (Pre-), during (In-), and after (Post-) spaceflight.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yayoi Kimura 

PROVIDER: PXD044609 | JPOST Repository | Mon Jan 22 00:00:00 GMT 2024

REPOSITORIES: jPOST

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20211013QE_DIA_JAXA_MP776_Flight_1_2.raw Raw
20211013QE_DIA_JAXA_MP776_Flight_2_1.raw Raw
20211013QE_DIA_JAXA_MP776_Flight_2_2.raw Raw
20211013QE_DIA_JAXA_MP776_Flight_3_1.raw Raw
20211013QE_DIA_JAXA_MP776_Flight_3_2.raw Raw
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The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative comprehensive proteome analysis performed with the data-independent acquisition method of mass spectrometry (DIA-MS). All six astronauts participated in a spaceflight mission for approximately 6 months a  ...[more]

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