Proteomics

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TOC1 and PRR5 as regulators of temperature compensation in the Arabidopsis circadian clock (12˚C vs 28˚C)


ABSTRACT: Ambient temperature potentially affects all biological systems. However, the period length of circadian clocks is close to 24 h over a broad range of physiological temperatures, known as temperature compensation. The mechanism underpinning the temperature compensation remains largely unknown. Here, we show that inhibitors of time progression, TIMING OF CAB EXPRESSION 1 (TOC1) and PSEUDO-RESPONSE REGULATOR 5 (PRR5) proteins, are required for the temperature compensation in Arabidopsis thaliana (Arabidopsis). Compared to the wild-type, the prr5 toc1 double mutant shows a short period at high temperatures. TOC1 and PRR5 proteins are ubiquitinated and degraded at low temperatures, by a ubiquitin E3 ligase LOV KELCH PROTEIN 2 (LKP2) that was sought as a minor player in the clock. The lkp2 mutants show long periods only at lower temperatures. Collectively, the clock keeps its periodicity against ambient temperature by the temperature-dependent quantity control of inhibitors of time progression. DOI:10.1126/sciadv.adq0187

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

SUBMITTER: Norihito Nakamichi 

PROVIDER: PXD044813 | JPOST Repository | Fri Oct 04 00:00:00 BST 2024

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
20230619_2023G49_e1.mzML Mzml
20230619_2023G49_e1.mzTab Mztab
20230619_2023G49_e10.mzML Mzml
20230619_2023G49_e11.mzML Mzml
20230619_2023G49_e12.mzML Mzml
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Publications

Cold-induced degradation of core clock proteins implements temperature compensation in the <i>Arabidopsis</i> circadian clock.

Maeda Akari E AE   Matsuo Hiromi H   Muranaka Tomoaki T   Nakamichi Norihito N  

Science advances 20240927 39


The period of circadian clocks is maintained at close to 24 hours over a broad range of physiological temperatures due to temperature compensation of period length. Here, we show that the quantitative control of the core clock proteins TIMING OF CAB EXPRESSION 1 [TOC1; also known as PSEUDO-RESPONSE REGULATOR 1 (PRR1)] and PRR5 is crucial for temperature compensation in <i>Arabidopsis thaliana</i>. The <i>prr5 toc1</i> double mutant has a shortened period at higher temperatures, resulting in weak  ...[more]

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