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Proteomics Analysis of 5-Fluorouracil- and Gemcitabine-Resistant Cholangiocarcinoma Cell Lines: Identification of Potential Therapeutic Targets and Prognostic Markers

ABSTRACT: Cholangiocarcinoma (CCA) poses a significant health challenge, especially in Asian countries. Late-stage diagnoses limit the availability of curative surgical options, underscoring the crucial role of chemotherapy. However, drug resistance presents a formidable obstacle, resulting in recurrent tumors. Despite the revolutionary impact of proteomics on cancer research, the exploration of drug-resistant mechanisms in CCA remains unexplored. In this study, we established 5-fluorouracil (5-FU)- and gemcitabine-resistant CCA cell lines, KKU-213FR and KKU-213GR, derived from the KKU-213A parental line. These cell lines exhibited robust drug resistance, heightened migration, and invasion capabilities.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Sumalee Obchoei

PROVIDER: PXD049309 | JPOST Repository | Wed Jul 03 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	KKU-213FR-1_1.mzXML	Mzxml
	KKU-213FR-1_2.mzXML	Mzxml
	KKU-213FR-1_3.mzXML	Mzxml
	KKU-213FR-2_1.mzXML	Mzxml
	KKU-213FR-2_2.mzXML	Mzxml

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