Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Sadr Shaheed
LAB HEAD: Dr Sadr ul Shaheed
PROVIDER: PXD047672 | Pride | 2024-06-16
REPOSITORIES: Pride
Ortega Duran Mario M Shaheed Sadr Ul SU Sutton Christopher W CW Shnyder Steven D SD
Cells 20240214 4
One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU). Whilst some resistance mechanisms are well known, it is clear from the stasis in therapy success rate that much is still unknown. Here, a proteomics approach is taken towards identification of candidate proteins using 5-FU-resistant sublines of human CRC cell lines generated in house. Using a multiplexed stable isotope labell ...[more]