Dataset Information
TD-MS analysis of single-domain antibody and anti-EGFR single-domain antibody-drug conjugate
Ontology highlight
ABSTRACT:
ORGANISM(S): Cellular Organisms
SUBMITTER: Benazza Rania, Letissier Léa
PROVIDER: PXD058380 | JPOST Repository | Tue Feb 11 00:00:00 GMT 2025
REPOSITORIES: jPOST
Dataset's files
Items per page: 1 - 5 of 20 |
Publications
Development of Top-Down Mass Spectrometry Strategies in the Chromatographic Time Scale (LC-TD-MS) for the Extended Characterization of an Anti-EGFR Single-Domain Antibody-Drug Conjugate in Both Reduced and Nonreduced Forms.
Analytical chemistry 20250131 5
Even though mAbs have attracted the biggest interest in the development of therapeutic proteins, next-generation therapeutics such as single-domain antibodies (sdAb) are propelling increasing attention as new alternatives with appealing applications in different clinical areas. These constructs are small therapeutic proteins formed by a variable domain of the heavy chain of an antibody with multiple therapeutic and production benefits compared with their mAb counterparts. These proteins can be s ...[more]
