Dataset Information

Metrics other than potency reveal systematic variation in responses to cancer drugs

ABSTRACT: -

SUBMITTER: Mohammad Fallahi-Sichani

PROVIDER: LDS-1106 | LINCS | 2016-05-06

REPOSITORIES: LINCS

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Publications

Metrics other than potency reveal systematic variation in responses to cancer drugs.

Fallahi-Sichani Mohammad M Honarnejad Saman S Heiser Laura M LM Gray Joe W JW Sorger Peter K PK

Nature chemical biology 20130908 11

Large-scale analysis of cellular response to anticancer drugs typically focuses on variation in potency (half-maximum inhibitory concentration, (IC50)), assuming that it is the most important difference between effective and ineffective drugs or sensitive and resistant cells. We took a multiparametric approach involving analysis of the slope of the dose-response curve, the area under the curve and the maximum effect (Emax). We found that some of these parameters vary systematically with cell lin ...[more]

PMID: 24013279

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