Multiomics

Dataset Information

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Basal profile of receptor tyrosine kinase signaling network measured by ELISA


ABSTRACT: -

SUBMITTER: Mario Niepel 

PROVIDER: LDS-1123 | LINCS | 2015-09-23

REPOSITORIES: LINCS

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Publications

Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines.

Niepel Mario M   Hafner Marc M   Pace Emily A EA   Chung Mirra M   Chai Diana H DH   Zhou Lili L   Schoeberl Birgit B   Sorger Peter K PK  

Science signaling 20130924 294


Identifying factors responsible for variation in drug response is essential for the effective use of targeted therapeutics. We profiled signaling pathway activity in a collection of breast cancer cell lines before and after stimulation with physiologically relevant ligands, which revealed the variability in network activity among cells of known genotype and molecular subtype. Despite the receptor-based classification of breast cancer subtypes, we found that the abundance and activity of signalin  ...[more]

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