Dataset Information

Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease

ABSTRACT: Human gut metaproteome of select healthy and disease cohort.

INSTRUMENT(S): LTQ Orbitrap (Thermo Fisher Scientific)

ORGANISM(S): Human Gut Metaproteome

SUBMITTER: Janet Jansson

PROVIDER: MSV000078958 | MassIVE | Mon Nov 24 16:47:00 GMT 2014

REPOSITORIES: MassIVE

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Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease.

Erickson Alison R AR Cantarel Brandi L BL Lamendella Regina R Darzi Youssef Y Mongodin Emmanuel F EF Pan Chongle C Shah Manesh M Halfvarson Jonas J Tysk Curt C Henrissat Bernard B Raes Jeroen J Verberkmoes Nathan C NC Fraser Claire M CM Hettich Robert L RL Jansson Janet K JK

PloS one 20121128 11

Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ileum (ICD) or colon (CCD). Integration of these omics approaches revealed several genes, proteins, and ...[more]

PMID: 23209564

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