Ontology highlight
ABSTRACT:
SUBMITTER: Erickson AR
PROVIDER: S-EPMC3509130 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121128 11
Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ileum (ICD) or colon (CCD). Integration of these omics approaches revealed several genes, proteins, and ...[more]