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Columbamide

ABSTRACT: Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering New Natural Products from Cyanobacteria Karin Kleigrewe, Jehad Almaliti, Isaac Yuheng Tian, Robin B. Kinnel, Anton Korobeynikov, Emily A. Monroe, Brendan M. Duggan, Vincenzo Di Marzo, David H. Sherman, Pieter Dorrestein, Lena Gerwick and William H. Gerwick

INSTRUMENT(S): ITMS, QTof

ORGANISM(S): Cyanobacteria (ncbitaxon:1117)

SUBMITTER: Gerwick

PROVIDER: MSV000079016 | MassIVE | Mon Jan 26 14:16:00 GMT 2015

REPOSITORIES: MassIVE

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Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria.

Kleigrewe Karin K Almaliti Jehad J Tian Isaac Yuheng IY Kinnel Robin B RB Korobeynikov Anton A Monroe Emily A EA Duggan Brendan M BM Di Marzo Vincenzo V Sherman David H DH Dorrestein Pieter C PC Gerwick Lena L Gerwick William H WH

Journal of natural products 20150707 7

An innovative approach was developed for the discovery of new natural products by combining mass spectrometric metabolic profiling with genomic analysis and resulted in the discovery of the columbamides, a new class of di- and trichlorinated acyl amides with cannabinomimetic activity. Three species of cultured marine cyanobacteria, Moorea producens 3L, Moorea producens JHB, and Moorea bouillonii PNG, were subjected to genome sequencing and analysis for their recognizable biosynthetic pathways, a ...[more]

PMID: 26149623

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