EMRE is an Essential Component of the Mitochondrial Calcium Uniporter Complex
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ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Steven A. Carr
PROVIDER: MSV000079095 | MassIVE | Fri Apr 03 08:28:00 BST 2015
SECONDARY ACCESSION(S): PXD002016
REPOSITORIES: MassIVE
Publications
EMRE is an essential component of the mitochondrial calcium uniporter complex.
Sancak Yasemin Y Markhard Andrew L AL Kitami Toshimori T Kovács-Bogdán Erika E Kamer Kimberli J KJ Udeshi Namrata D ND Carr Steven A SA Chaudhuri Dipayan D Clapham David E DE Li Andrew A AA Calvo Sarah E SE Goldberger Olga O Mootha Vamsi K VK
Science (New York, N.Y.) 20131114 6164
The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU). We sought to achieve a full molecular characterization of the uniporter holocomplex (uniplex). Quantitative mass spectrometry of affinity-purified uniplex recovered MICU1 and MICU2, MCU and its paralog ...[more]
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