Dataset Information
Identification SETD1A-binding proteins by Co-IP MS
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE108615
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Alex Kentsis
PROVIDER: MSV000080012 | MassIVE | Mon Aug 01 12:48:00 BST 2016
SECONDARY ACCESSION(S): PXD004697
REPOSITORIES: MassIVE
Publications
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.
Cell 20180201 5
MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas9 domain screening show the enzymatic SET domain is not necessary for AML cell survival but that a newly identified region termed the "FLOS" (functional location on SETD1A) domain is indispensable. FLOS disruption suppresses DNA d ...[more]
