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ZNF598 substrate identification

ABSTRACT: This study uses ubiquitin proteomics to identify substrates for the ZNF598 ubiquitin ligase

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Eric Bennett

PROVIDER: MSV000080390 | MassIVE | Thu Dec 08 13:43:00 GMT 2016

REPOSITORIES: MassIVE

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Publications

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.

Sundaramoorthy Elayanambi E Leonard Marilyn M Mak Raymond R Liao Jeffrey J Fulzele Amitkumar A Bennett Eric J EJ

Molecular cell 20170126 4

Ribosomes that experience terminal stalls during translation are resolved by ribosome-associated quality control (QC) pathways that oversee mRNA and nascent chain destruction and recycle ribosomal subunits. The proximal factors that sense stalled ribosomes and initiate mammalian ribosome-associated QC events remain undefined. We demonstrate that the ZNF598 ubiquitin ligase and the 40S ribosomal protein RACK1 help to resolve poly(A)-induced stalled ribosomes. They accomplish this by regulating di ...[more]

PMID: 28132843

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