Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Nerea Osinalde
PROVIDER: MSV000080767 | MassIVE | Wed Mar 29 12:11:00 BST 2017
SECONDARY ACCESSION(S): PXD001129
REPOSITORIES: MassIVE
Osinalde Nerea N Sanchez-Quiles Virginia V Akimov Vyacheslav V Guerra Barbara B Blagoev Blagoy B Kratchmarova Irina I
Proteomics 20140930 2-3
Common γ-chain family of cytokines (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, where IL stands for interleukin) are key regulators of the immune homeostasis that exhibit pleiotropic biological activities and even sometimes redundant roles as a result of the utilization of the same receptor subunit. However, they also exert distinct functions that make each of them to be indispensable. For instance, all family members can act as T-cell growth factors; however, we found that IL-15 but not IL-7 can ...[more]