Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Edward W. Tate
PROVIDER: MSV000080782 | MassIVE | Wed Mar 29 14:01:00 BST 2017
SECONDARY ACCESSION(S): PXD002601
REPOSITORIES: MassIVE
Molecular & cellular proteomics : MCP 20151124 2
AMPylation of mammalian small GTPases by bacterial virulence factors can be a key step in bacterial infection of host cells, and constitutes a potential drug target. This posttranslational modification also exists in eukaryotes, and AMP transferase activity was recently assigned to HYPE Filamentation induced by cyclic AMP domain containing protein (FICD) protein, which is conserved from Caenorhabditis elegans to humans. In contrast to bacterial AMP transferases, only a small number of HYPE subst ...[more]