Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Remigiusz Serwa
LAB HEAD: Edward W. Tate
PROVIDER: PXD002601 | Pride | 2015-12-02
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
AMPylation_HYPE.mgf | Mgf | |||
AMPylation_HYPEpeptides.pep.xml | Pepxml | |||
ATP1.mgf | Mgf | |||
ATP1peptides.pep.xml | Pepxml | |||
ATP2.mgf | Mgf |
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Molecular & cellular proteomics : MCP 20151124 2
AMPylation of mammalian small GTPases by bacterial virulence factors can be a key step in bacterial infection of host cells, and constitutes a potential drug target. This posttranslational modification also exists in eukaryotes, and AMP transferase activity was recently assigned to HYPE Filamentation induced by cyclic AMP domain containing protein (FICD) protein, which is conserved from Caenorhabditis elegans to humans. In contrast to bacterial AMP transferases, only a small number of HYPE subst ...[more]