Proteomics

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Human colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS

ABSTRACT: The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, could reveal novel insights into the diseases. Mucosal colonic biopsies were extracted by standard colonscopy from sigmoideum from 10 ulcerative colitis patients from non-inflammed tissue and 10 controls. The biopsies were immediately following extraction snap-frozen for protein analysis and the protein content of the biopsies was characterized by high-throughput quantative gel-free proteomics.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Allan Stensballe  

PROVIDER: MSV000080833 | MassIVE | Fri Mar 31 17:12:00 BST 2017

SECONDARY ACCESSION(S): PXD001608

REPOSITORIES: MassIVE

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Neutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsies.

Bennike Tue Bjerg TB   Carlsen Thomas Gelsing TG   Ellingsen Torkell T   Bonderup Ole Kristian OK   Glerup Henning H   Bøgsted Martin M   Christiansen Gunna G   Birkelund Svend S   Stensballe Allan A   Andersen Vibeke V  

Inflammatory bowel diseases 20150901 9

<h4>Background</h4>The etiology of the inflammatory bowel diseases, including ulcerative colitis (UC), remains incompletely explained. We hypothesized that an analysis of the UC colon proteome could reveal novel insights into the disease etiology.<h4>Methods</h4>Mucosal colon biopsies were taken by endoscopy from noninflamed tissue of 10 patients with UC and 10 controls. The biopsies were either snap-frozen for protein analysis or prepared for histology. The protein content of the biopsies was c  ...[more]

PMID: 25993694

Publication: 1/2

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