Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Ronald Thomas Hay
PROVIDER: MSV000080852 | MassIVE | Fri Mar 31 23:05:00 BST 2017
SECONDARY ACCESSION(S): PXD004995
REPOSITORIES: MassIVE
Molecular & cellular proteomics : MCP 20161202 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino acid side-chains, leading to the possibility that aspirin-mediated lysine acetylation could explain some of its as-yet unexplained drug actions or side-effects. Using isotopically labeled aspirin-d<sub>3</sub>, in combination with acetylated lysine pur ...[more]