Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Mike Tatham
LAB HEAD: Ronald Thomas Hay
PROVIDER: PXD003530 | Pride | 2017-01-10
REPOSITORIES: Pride
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20120301_MT_Asp_D0.raw | Raw | |||
20120301_MT_Asp_D0_8ul.raw | Raw |
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Molecular & cellular proteomics : MCP 20161202 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino acid side-chains, leading to the possibility that aspirin-mediated lysine acetylation could explain some of its as-yet unexplained drug actions or side-effects. Using isotopically labeled aspirin-d<sub>3</sub>, in combination with acetylated lysine pur ...[more]