Proteomics

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Lambert_BRD_SAINT2307_JQ1_APMS_time_course_TripleTOF_P82_VS5

ABSTRACT: This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. More precisely, files used in the SAINT express task 2307 are in this dataset. The AP-MS experiments involving a JQ1 time-course for 3xFLAG tagged BET proteins acquired on TripleTOF 5600 spectrometers are found here; please note that the SWATH/DIA files were used for quantification (MSPLIT-DIA) while the DDA files were used for library construction. See the README file within "Materials and Methods" and the accompanying files for a complete description of MS data generated.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000081006 | MassIVE | Tue Apr 25 17:20:00 BST 2017

REPOSITORIES: MassIVE

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Publications

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical  ...[more]

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