Proteomics

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SAINT_3727_JQ1_APMS_endoK562_P82_VS17_28AUG2018

ABSTRACT: This submission contains the mass spectrometry files for the manuscript by Lambert, Picaud et al. that describes the characterization of interactome changes induced by JQ1 on the BET proteins. This submission contains 16 files associated with endogenous IP-MS analysis of BRD2, BRD3 and BRD4 (IgG was used as a negative control) from K562 cells treated with (+)-JQ1 or DMSO for 1 h; biological duplicate analyses were performed. Sample were analysed on a TripleTOF 5600 spectrometer; please note that the SWATH/DIA files were used for quantification (MSPLIT-DIA) while the DDA files were used for library construction. See the README file within "Materials and Methods" and the accompanying files for a complete description of MS data generated.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000082859 | MassIVE | Tue Aug 28 14:03:00 BST 2018

SECONDARY ACCESSION(S): PXD010916

REPOSITORIES: MassIVE

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Publications

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A group of proteins associate in a JQ1-sensitive manner with BET BRDs through canonical  ...[more]

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